Leukotriene C4 synthase



Leukotriene C4 synthase (LC4S) converts leukotriene A4 and glutathione to leukotriene C4. It is part of the arachidonic acid cycle. The images at the left and at the right correspond to one representative LC4S, i.e. the crystal structure of human Leukotriene C4 synthase (2uui).

3D Structures of Leukotriene C4 synthase
Update June 2011

2pno, 2uui, 3pcv – hLC4S - human

3leo – hLC4S (mutant)+glutathione

3hkk, 2uuh - hLC4S +glutathione